Complex Regional Pain Syndrome (CRPS) is a chronic and often debilitating condition that affects the nerves and causes severe, persistent pain. Studies show that CRPS affects approximately 200,000 people in the United States each year, with symptoms often developing after an injury, surgery, or other trauma. The condition is characterized by burning pain, swelling, stiffness, and changes in skin color or temperature, making daily activities incredibly difficult.
At OrthoGen Health, we provide non-surgical regenerative medicine therapies to help patients suffering from CRPS find relief. Using advanced treatments like platelet-rich plasma (PRP), exosome therapy, and stem cell therapy, we aim to reduce nerve inflammation, support healing, and restore function naturally.
“Someone referred me to this place because i had a very bad knee pain which multiple other doctors i visited, told me have to have an open surgery but Dr.James told me can do PRP which is much easier and safer. I thought it worth trying it. After almost 2 years, i still have no pain and i got back to normal life. I am so glad listen to Dr, James and for your info i think he has one of the highest certificates that only a few doctors in the US have it.
He is so kind and acknowledgeable and i definitely recommend anyone who has joint pain before letting others to have any open surgeries which obviously they want nothing but making money.Thanks you for making the life enjoyable for me again.”
How Regenerative Medicine Relieves CRPS Discomfort
Traditional CRPS treatments, such as pain medications, nerve blocks, and physical therapy, often provide only limited relief. Regenerative medicine takes a different approach by promoting nerve healing and reducing chronic inflammation at the source.
Platelet-Rich Plasma (PRP) Therapy
PRP contains powerful growth factors that help repair nerve damage, enhance circulation, and reduce pain sensitivity.
Exosome Therapy Exosomes
Serve as cellular messengers, improving nerve function and reducing inflammatory responses.
Stem Cell Therapy
Stem cells promote nerve regeneration, helping to restore normal sensation and reduce chronic pain.
Biologic Injections
These injections provide long-lasting pain relief by addressing underlying nerve dysfunction and tissue damage.
Research suggests that PRP and stem cell therapy may help improve nerve function and pain levels in patients with CRPS, making regenerative medicine a promising treatment option.
Symptoms and Causes of CRPS
CRPS typically develops after an injury, surgery, or prolonged immobilization, and symptoms may include:
- Severe, burning pain that spreads beyond the initial injury site
- Extreme sensitivity to touch and temperature changes
- Swelling, skin discoloration, or changes in skin texture
- Joint stiffness and muscle weakness
- Abnormal sweating or changes in hair and nail growth

Frequently Asked Questions About Regenerative Therapy for CRPS
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While CRPS is a complex condition, regenerative treatments can help reduce nerve hypersensitivity, promote healing, and improve quality of life.
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Unlike medications or nerve blocks that only provide temporary relief, regenerative medicine targets the root cause of nerve dysfunction.
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Yes, PRP, stem cell, and exosome therapy are minimally invasive and use the body’s own biological materials, making them a safe alternative.
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Many patients experience pain reduction and improved mobility within a few weeks, with continued healing over time.

Dr. James Petros
Dr. James Petros, founder of OrthoGen Health, is a board-certified regenerative medicine physician with extensive expertise in pain management and non-surgical orthopedics. Now serving primarily in his role as CEO, Dr. Petros focuses on advancing the mission of OrthoGen Health through innovation, clinical leadership, and patient-centered strategy. He has built the organization on a foundation of scientific progress, compassionate care, and collaboration, ensuring that patients are supported by a team dedicated to delivering the highest quality regenerative therapies.
Find a Natural Solution to CRPS in San Jose
If you are struggling with chronic pain due to Complex Regional Pain Syndrome, OrthoGen Health in San Jose and Los Gatos offers advanced regenerative medicine therapies to help manage symptoms and restore function naturally.
Schedule a consultation today to explore your options for non-surgical CRPS treatment and long-term pain relief.