Chronic joint pain and instability affect millions of Americans, often resulting from ligament laxity, overuse injuries, and degenerative conditions like osteoarthritis. Many patients turn to pain medications, steroid injections, or even surgery, but these solutions only provide temporary relief or come with long recovery times and risks. Prolotherapy is a safe, non-surgical regenerative treatment designed to strengthen ligaments, stabilize joints, and reduce chronic pain naturally.
At OrthoGen Health, our expert team offers prolotherapy as a minimally invasive alternative to surgery or long-term medication use. Our mission is to provide advanced regenerative medicine solutions that promote natural healing and restore mobility.
“Someone referred me to this place because i had a very bad knee pain which multiple other doctors i visited, told me have to have an open surgery but Dr.James told me can do PRP which is much easier and safer. I thought it worth trying it. After almost 2 years, i still have no pain and i got back to normal life. I am so glad listen to Dr, James and for your info i think he has one of the highest certificates that only a few doctors in the US have it.
He is so kind and acknowledgeable and i definitely recommend anyone who has joint pain before letting others to have any open surgeries which obviously they want nothing but making money.Thanks you for making the life enjoyable for me again.”

What is Prolotherapy?
Prolotherapy, also known as proliferative therapy or regenerative injection therapy, involves injecting a natural irritant solution, typically dextrose-based, into damaged ligaments, tendons, or joints. This controlled irritation triggers the body’s natural healing response, leading to the growth of new, stronger connective tissue that stabilizes and supports the joint.
How Prolotherapy Works
Prolotherapy works by initiating a localized healing response, stimulating tissue repair and collagen production. The process includes:
- Injection of Dextrose Solution: A mild irritant (typically dextrose, a type of sugar) is injected into the affected joint, ligament, or tendon.
- Activation of Natural Healing: The injection stimulates the body’s repair mechanisms, encouraging the production of new, strong connective tissue.
- Strengthening of Ligaments & Tendons: Over time, the treated area becomes more stable, reducing pain and improving function.
Conditions Treated with Prolotherapy
Prolotherapy is particularly beneficial for chronic pain conditions caused by joint instability, ligament damage, or soft tissue injuries. It is commonly used to treat:
Osteoarthritis
Strengthens weakened joints and slows cartilage breakdown.
Chronic Joint Instability
Restores stability to loose or hypermobile joints.
Tendonitis & Ligament Sprains
Stimulates tissue regeneration to repair chronic soft tissue injuries.
Lower Back & Neck Pain
Helps stabilize spinal structures and reduce discomfort.
Knee, Hip, Shoulder & Ankle Pain
Supports joint function and long-term pain relief.

Benefits of Prolotherapy for Pain & Healing
Prolotherapy offers a non-surgical, long-term solution for chronic pain sufferers, with key benefits such as:
Strengthened Connective Tissue
Promotes the growth of new ligaments and tendons, restoring joint integrity.
Reduced Chronic Pain
Alleviates pain by enhancing joint stability and reducing inflammation.
Minimally Invasive & Safe
Uses a natural solution with minimal downtime and low risk of complications.
Improved Mobility & Function
Helps patients regain range of motion and flexibility without surgery.

Dr. James Petros
Dr. James Petros, founder of OrthoGen Health, is a board-certified regenerative medicine physician with extensive expertise in pain management and non-surgical orthopedics. Now serving primarily in his role as CEO, Dr. Petros focuses on advancing the mission of OrthoGen Health through innovation, clinical leadership, and patient-centered strategy. He has built the organization on a foundation of scientific progress, compassionate care, and collaboration, ensuring that patients are supported by a team dedicated to delivering the highest quality regenerative therapies.
Restore Stability & Reduce Pain with Prolotherapy in San Jose
If you suffer from chronic joint pain, ligament injuries, or instability, OrthoGen Health in San Jose and Los Gatos offers state-of-the-art prolotherapy to help strengthen joints and provide lasting relief.
Schedule a consultation today to explore how prolotherapy can promote natural healing and reduce chronic pain without surgery.